Astaxanthin

High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs.

Kim JH, Kang SW, Kim SW, Chang HI.

Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, South Korea.

Medium composition was optimized for high-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Glucose and yeast extract were the most important factors affecting astaxanthin production. Glucose 3.89%, yeast extract 0.29%, KH2PO4 0.25%, MgSO4 0.05%, MnSO4 0.02%, and CaCl2 0.01% were optimum for high-level production of astaxanthin. Under optimized conditions, the maximum concentration of astaxanthin obtained after 7 d of cultivation was 36.06 mg/l. The concentration of astaxanthin predicted by a polynomial model was 36.16 mg/l.

PMID: 16195593 [PubMed - indexed for MEDLINE]