Chondroitin

Blood coagulation initiates respiratory burst in neutrophils.

Gerasimov IG, Ignatov DY.

Institute for Medical Problems of Family, M. Gorky Donetsk State Medical University.

Using the in vitro reaction of nitroblue tetrazolium reduction we showed that blood coagulation stimulates production of reactive oxygen species by human neutrophils. Heparin and chondroitin sulfate produced by thrombin-activated basophils are good candidates for inductors of these processes. Similar activation probably occurs in vivo under the influence of inductors secreted by mast cells.

PMID: 16254626 [PubMed - indexed for MEDLINE]

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