Chondroitin

Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating TH2 responses in mice.

Sakai S, Akiyama H, Sato Y, Yoshioka Y, Linhardt RJ, Goda Y, Maitani T, Toida T.

Division of Foods, National Institute of Health Sciences, Tokyo, Tokyo 158-8501.

Chondroitin sulfate (CS) was administered orally to BALB/c mice immunized intraperitoneally with ovalbumin (OVA) and/or dinitrophenylated (DNP)-OVA. The titers of antigen-specific IgE and IgG1 in mouse sera were determined. The antigen-specific IgE production by mice fed "ad libitum" with CS was significantly inhibited. We also examined the effect of feeding CS on immediate-type hypersensitivity. One hour after antigen stimulation, the ears of mice fed with CS swelled less than those of the control mice. Furthermore, the rise in serum histamine in the mice fed with CS under active systemic anaphylaxis was significantly lower than that in the controls. We next examined the pattern of cytokine production by splenocytes from mice followed by restimulation with OVA in vitro. The splenocytes from the mice fed with CS produced less interleukin (IL)-5, IL-10 and IL-13 than those from the control group. In contrast, the production of interferon-gamma (IFN-gamma) and IL-2 by the splenocytes of mice fed with CS were not significantly different from those in the control mice. In addition, the production of transforming growth factor-beta (TGF-beta)from the splenocytes of mice fed with CS was significantly higher than that of the control mice. Furthermore, we showed that the percentages of CD4(+) cells, CD8(+) cells and CD4(+)CD25(+) cells in the splenocytes of mice fed with CS are significantly higher than those of the control. These findings suggest that oral intake of CS inhibits the specific IgE production and antigen-induced anaphylactic response by up-regulating regulatory T cell differentiation, followed by down-regulating the Th2 response.

PMID: 16624819 [PubMed - as supplied by publisher]

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