Chondroitin

Clinical Studies

Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord.

Loss of perineuronal net N-acetylgalactosamine in Alzheimer's disease.

Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.

Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomy.

Evidence for proteolytic cleavage of brevican by the ADAMTSs in the dentate gyrus after excitotoxic lesion of the mouse entorhinal cortex.

Demonstration of the pleiotrophin-binding oligosaccharide sequences isolated from chondroitin sulfate/dermatan sulfate hybrid chains of embryonic pig brains.

Regulation of the chondroitin/dermatan fine structure by transforming growth factor-beta1 through effects on polymer-modifying enzymes.

Local bradykinin formation is controlled by glycosaminoglycans.

Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2.

Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity.

Macrophages accumulate in the early phase of tendon-bone healing.

Glycosaminoglycans modulate C6 glioma cell adhesion to extracellular matrix components and alter cell proliferation and cell migration.

Versican splice variants in human trabecular meshwork and ciliary muscle.

Biochemical characterization of the chondroitinase ABC I active site.

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.

Poly (D,L-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord.

Dielectric properties of the collagen-glycosaminoglycans scaffolds in the temperature range of thermal decomposition.

In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury.

Preparation of the methyl ester of hyaluronan and its enzymatic degradation.

Nutritional factors and osteoarthritis: recent developments.

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